Kulathinal Lab High-throughput Journal Club
Tuesdays at 4pm (BioLife 213A)
Kulathinal Lab Population Genetics Journal Club
Wednesdays at 4pm (BioLife 213A)
Department of Biology Seminar
Mondays at 4:00 (BioLife 234)
This semester's special theme: "Ecological Speciation"
Tuesdays 11:30-12:30 (BioLife 237)
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Philly-area Seminars info >
Hansen EB & Kulathinal RJ. 2013. Sex-biased networks and nodes of sexually antagonistic conflict in Drosophila.. International Journal of Evolutionary Biology 2013:545392
Kulathinal RJ & Singh RS. 2012. Sexual system genomics and speciation. In "Rapidly evolving genes and genetic systems" (Eds: Singh, Xu, and Kulathinal), Oxford University Press, London.
Sackton TB, Kulathinal RJ, Bergman CM, Quinlan AR, Dopman EB, Carneiro M, Marth GT, Hartl DL & Clark AG. 2009. Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Genome Biol. Evol. 1:439–455
Kulathinal RJ, Stevison LS & Noor MAF. 2009. The genomics of speciation in Drosophila: Diversity, divergence and introgression estimated from low-coverage whole genome shotgun sequences. PLoS Genetics 5:e1000550
Kulathinal RJ, Bennett SM, Fitzpatrick CL & Noor MAF. 2008. Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence. Proceedings of the National Academy of Sciences U.S.A. 105:10051-10056
Kulathinal RJ & Singh RS. 2008. The molecular basis of speciation: From patterns to processes, rules to mechanisms. Journal of Genetics 87:327
Singh RS & Kulathinal RJ. 2005. Male-drive and the masculination of the genome. BioEssays 27:518-525
Kulathinal RJ, Bettencourt BR & Hartl DL. 2004. Compensated deleterious mutations in insect genomes. Science:1553-1554
Our lab is interested in rapidly evolving genes, traits, and genetic networks, and the role they play in phenotypic and species divergence. Our primary focus lies in understanding how variation within species can quickly transform into the tremendous diversity observed among species, a process known as speciation. To address this grand challenge, we use a combination of experimental, theoretical, and computational approaches that allow us to explore genomic landscapes from natural populations in order to compare selective signatures across functional networks and to tease apart the various forces involved in species formation. While our favorite model system is Drosophila, we use other species with good and plentiful data. The availability of novel datasets, particularly from new sequencing technologies and initiatives, provides us with an unprecedented number of unexplored landscapes to study the genomic architecture of rapidly evolving systems.
Rob J. Kulathinal, PhD
Ralph Hillman, PhD
Meganathan Ramakodi, PhD
Fang Zhou, PhD
Dr. Kulathinal's Office: BioLife Room 214
Molecular and Fly Lab: BioLife Room 213
Computational Lab: BioLife Room 213A
Behavioral Lab: BioLife Room 436
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There are a number of exciting opportunities in the Kulathinal lab for motivated students interested in evolutionary biology, genetics, genomics and/or bioinformatics.
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